Die Silberkornkrankheit – Abgrenzung zur Alzheimer’schen Erkrankung

@article{Tolnay1999DieS,
  title={Die Silberkornkrankheit – Abgrenzung zur Alzheimer’schen Erkrankung},
  author={Markus Tolnay and Andreas U. Monsch and Hannes B. Staehelin and A. Probst},
  journal={Der Pathologe},
  year={1999},
  volume={20},
  pages={159-168}
}
ZusammenfassungDie Silberkornkrankheit ist eine Demenzform des hohen Alters, die feingeweblich durch das Vorhandensein zahlreicher Silberkörner und sogenannter „coiled bodies” charakterisiert ist. Beide Veränderungen sind im limbischen System (vor allem CA1-Abschnitt des Hippocampus, entorhinale Rinde, Mandelkern) und im Hypothalamus lokalisiert. Die Silberkörner lassen sich mit Hilfe geeigneter Versilberungsmethoden einfach darstellen und sind gut von neurofibrillären Läsionen der Alzheimer… 
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References

SHOWING 1-10 OF 50 REFERENCES
Das Normgewicht des Gehirns beim Erwachsenen in Abhängigkeit von Alter, Geschlecht, Körpergröße und Gewicht
ZusammenfassungAnhand von über 8000 Autopsien von Patienten ohne Hirnkrankheiten wurden die Normgewichte der Gehirne für Männer und Frauen in Abhängigkeit von Alter, Körpergröße, Gewicht und Body
Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy?
TLDR
It is suggested that the late onset dementia with argyrophilic grains syndrome is also characterized by the presence of tangles and threads with the topographical distribution of progressive supranuclear palsy.
Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria
TLDR
The fact that the same material contained 146 cases of fully developed Alzheimer's disease (6%) supports the view that argyrophilic grain disease is not a rare disorder.
Neurodegenerative disorders with extensive tau pathology: A comparative study and review
TLDR
Comparison of tau‐immunoreactive lesions in three relatively uncommon neurodegenerative diseases—progressive supranuclear palsy, Pick's disease, and corticobasal degeneration—illustrates the types of analyses that demonstrate unexpeceted pathological similarities, but also fundamental differences between these disorders.
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease
TLDR
The present findings support the concept that AGD is a distinct neurodegenerative entity afflicting not only cortical but also subcortical predilection sites of the human brain.
Dementia with Grains (Argyrophilic Grain Disease)
Dementia with grains, also referred to as argyrophilic grain disease, is a morphological condition in elderly individuals histologically characterised by the widespread occurrence of minute, spindle
Prevalence and Disease Associations of Argyrophilic Grains of Braak
TLDR
It is concluded that rather than defining a single disease, BAG constitute lesions that accompany several degenerative diseases, but also occur in normal elderly subjects, and rarely in demented subjects without other major histological findings.
The Neurofibrillary Pathology of Alzheimer's Disease
TLDR
Recent results suggest that an interaction between tau protein and sulfated glycosaminoglycans may play an important role in inducing both the hyperphosphor ylation of tau and the formation of paired helical and straight filaments.
Low amyloid (Aβ) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer’s disease
TLDR
The present study further supports the thesis that dementia in argyrophilic grain disease correlates more with the density and distribution of argyophilic grains than with associated lesions of the Alzheimer‐type.
Argyrophilic grain disease: distribution of grains in patients with and without dementia
TLDR
The results show that the intellectual status of patients with AgD was related to the extension of ArG in the limbic area, suggesting that AgD is a progressive neurodegenerative disorder with early subclincial lesions in the anterior part of the hippocampal formation.
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