Die Rolle der diabetischen Neuropathie bei der Genese des Charcot-Fußes

  title={Die Rolle der diabetischen Neuropathie bei der Genese des
  author={M. F. Dohrn and S. Kessler and M. Dafotakis},
  journal={Klinische Neurophysiologie},
Die neuropathische Osteo(arthro-)pathie, auch Charcot-Fus genannt, ist eine progressive, nicht-infektiose Schwellung mit Uberwarmung und Demineralisierung, gefolgt von Knochendestruktion und Deformierung, die in ca. 75% unilateral auftritt und in einer Defektheilung zum Stillstand kommt. Resultierende Fehlstellungen konnen zu neuropathischen Ulzera fuhren, die sich infizieren und Amputationen erforderlich machen konnen. Die haufigste, aber nicht einzige Ursache ist der Diabetes mellitus… Expand
3 Citations
Ursachen, Spektrum und Therapie der diabetischen Neuropathie
Hintergrund Die Hälfte aller Diabetiker ist von einer diabetischen Neuropathie betroffen. Mikroangiopathie, dysfunktionale Schwann-Zell-Interaktion, Akkumulation toxischer Metabolite undExpand
Stellenwert klinischer, funktioneller und bildgebender Diagnostik zur Früherkennung, Differenzialdiagnose und Verlaufskontrolle diabetischer Neuropathien
Eine prazise Ausschluss- and Ausmasdiagnostik ist entscheidend, um andere behandelbare Erkrankungen wie z. Expand
[Causes, spectrum, and treatment of the diabetic neuropathy].
The diabetic neuropathy is frequent and causes severe complications, and a good understanding of the underlying pathophysiology can contribute to the development of novel treatment strategies in the future. Expand


Charcot neuro‐osteoarthropathy
  • W. Jeffcoate
  • Medicine
  • Diabetes/metabolism research and reviews
  • 2008
It has been suggested that acute CN may be triggered in a susceptible individual by any event that leads to localized inflammation in the affected foot, which leads to a vicious cycle in which there is increasing inflammation, increasing expression of RANKL, and increasing bone breakdown. Expand
The Bruns-Garland syndrome (diabetic amyotrophy). Revisited 100 years later.
The cases and others cast doubt on notions supporting two distinct types of proximal diabetic neuropathies represented by the rapid evolution of asymmetric weakness on an ischemic basis in contrast to a more slowly progressive condition of metabolic pathogenesis. Expand
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)
The hypothesis that CRPS‐I is specifically associated with post‐traumatic focal MDNI affecting nociceptive small‐fibers affecting subserve pain and autonomic function is supported. Expand
Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome
In CRPS affected skin, several neuropathologic alterations were detected, including the presence of numerous abnormal thin caliber NF‐positive/MBP‐negative axons innervating hair follicles and a loss of vascular endothelial integrity and extraordinary vascular hypertrophy. Expand
Prevalence of polymorphisms in OPG, RANKL and RANK as potential markers for Charcot arthropathy development
The results suggest that analysis of multiple SNPs can be used as potential marker of Charcot arthropathy and provide insight into possible molecular mechanisms of its development. Expand
Update on the pathogenesis of diabetic neuropathy
The findings obtained in 1999 to 2003 support the role of previously established mechanisms and reveal the importance of new downstream effectors of oxidative injury. Expand
The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
Evidence is provided that RANKL/RANK/OPG signaling is modulated in patients with CN and plays a role in vascular calcification, highlighting this pathway as a potential target for intervention. Expand
An Update on the Pathophysiology of Complex Regional Pain Syndrome
Enhanced knowledge regarding the pathophysiology of CRPS increases the possibility of eventually achieving the goal of mechanism-based CRPS diagnosis and treatment. Expand
Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity
The performance characteristics of several criteria for the diagnosis of sensorimotor polyneuropathy in healthy subject‐ and diabetic subject cohorts are provided and staged and continuous approaches to estimate severity of DSPN are outlined. Expand
Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).
Using the CPIP model, it is demonstrated that NFkappaB is involved in the development of allodynia after a physical injury (ischemia and reperfusion) without direct nerve trauma. Expand