The tissue factor pathway: how it has become a "prima ballerina".
- Chemistry, Medicine
- Thrombosis and haemostasis
Exposure of blood in vitro to a negatively charged surface such as glass triggers coagulation not by releasing TF but by activating the plasma protein, factor XII (Hageman factor) (6). Expand
Effect of fat on the vitamin K requirement of the chick.
A study has bean made of the relationship of dietary fat to the vitamin K requirement of the chick. In these experiments, the vitamin K status of chicks was measured by determining the blood… Expand
Structure and function of factor X: properties, activation, and activity in prothrombinase. A retrospective in a historical context
- Journal of Thrombosis and Thrombolysis
The evolution of the authors' understanding of the formation of thrombin from the postulated thrombokinase of Morawitz to activated Factor X and prothrombinase occurred during a period of nearly 100 years and the roles of phospholipid surfaces, the accessory factor, Factor V and its activated form have been clarified. Expand
A History of Coagulopathy in Liver Disease: Legends and Myths
- Clinical liver disease
Watch an interview with the author.
Beyond thrombosis: the impact of tissue factor signaling in cancer
- Chemistry, Medicine
- Journal of Hematology & Oncology
The regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics are reviewed in detail. Expand
Calcium functioned carboxymethylated cotton fabric for hemostatic wound dressing
Massive hemorrhage is a frequent cause of human death in the operating room and other emergency situations. Therefore, effective hemostatic wound dressings are essential to save lives. Here we show… Expand
Aspects of platelet transfusions and the association between routine coagulation tests and outcome
Study III, a retrospective cohort study, showed that prolonged APTT and increased PT-INR on admission to the ICU correlated with increased mortality in patients with severe sepsis or septic shock and the need for vasopressors and renal replacement therapy. Expand
Revisiting the Pharmacology of Unfractionated Heparin
- Clinical Pharmacokinetics
A comprehensive mechanistic approach to the interaction of UFH with the haemostatic system is provided, the effect of chemical structure on its PK and PD properties is quantitatively described, and a framework for characterisation of the dose–response relationship of UFH for the purpose of dose optimisation is proposed. Expand
Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis.
- Seminars in thrombosis and hemostasis
The authors summarize the current understanding of the role of TF in both cancer progression and cancer-associated thrombosis, and discuss novel insights on TF as a therapeutic target as well as a biomarker for cancer progressions and VTE. Expand
Biology of Coagulation and Coagulopathy in Neurologic Surgery.
- Neurosurgery clinics of North America
Standard laboratory assays, including the PT and aPTT, do not accurately reflect the complexity of hemostasis in vivo; therefore, they cannot predict the risk of bleeding or thrombosis. Expand
SHOWING 1-10 OF 38 REFERENCES
The immediate action of an intravenous injection of blood‐serum
- Medicine, Chemistry
- The Journal of physiology
It is found that the intravenous injection of diluted blood-serum into a cat produced a marked effect upon the heart and respiration, and several other substances, e.g. egg-white and the bromine compounds of proteids, could produce the same effect, but in the experiments described in this paper serum has been chiefly employed. Expand
Ueber die Beziehungen der Leber- und Blutveränderungen bei Phosphorvergiftung zur Autolyse.
Der Antagonismus gerinnungsbefördernder und gerinnungshemmender Stoffe im Blute und die sogenannte Pepton-Immunität.