Didanosine-loaded chitosan microspheres optimized by surface-response methodology: a modified "Maximum Likelihood Classification" approach formulation for reverse transcriptase inhibitors.

@article{Silva2015DidanosineloadedCM,
  title={Didanosine-loaded chitosan microspheres optimized by surface-response methodology: a modified "Maximum Likelihood Classification" approach formulation for reverse transcriptase inhibitors.},
  author={Classius Ferreira da Silva and Patr{\'i}cia Severino and Fernanda L Martins and Maria Helena Andrade Santana and E. Souto},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2015},
  volume={70},
  pages={46-52}
}
Didanosine-loaded chitosan microspheres were developed applying a surface-response methodology and using a modified Maximum Likelihood Classification. The operational conditions were optimized with the aim of maintaining the active form of didanosine (ddI), which is sensitive to acid pH, and to develop a modified and mucoadhesive formulation. The loading of… CONTINUE READING