Did the first adaptive immunity evolve in the gut of ancient jawed fish?

@article{Matsunaga1998DidTF,
  title={Did the first adaptive immunity evolve in the gut of ancient jawed fish?},
  author={Takeshi Matsunaga},
  journal={Cytogenetics and cell genetics},
  year={1998},
  volume={80 1-4},
  pages={138-41}
}
Gut-associated immune tissue, as represented by lymphocytes and lymphoid cell aggregates, occurs in all jawed vertebrates. Considering the lymphopoietic function of the cryptopatches in the mouse intestine, the lymphoid aggregates in the gastrointestinal lamina propria of birds and cold-blooded vertebrates seem to serve the same function, thus providing an explanation for their conservation during a period of over 400 million years. Some gammadelta+ intraepithelial T cells are likely to develop… CONTINUE READING

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