• Chemistry, Medicine
  • Published in
    Origins of life and evolution…
    1986
  • DOI:10.1007/BF01809810

Did template-directed nucleation precede molecular replication?

@article{Orgel1986DidTN,
  title={Did template-directed nucleation precede molecular replication?},
  author={Leslie E. Orgel},
  journal={Origins of life and evolution of the biosphere},
  year={1986},
  volume={17},
  pages={27-34}
}
It is proposed that mononucleotides incorporated into the surfaces of microcrystals of inorganic phosphates such as hydroxyapatite can act as templates to assemble complementary mononucleotides from solution, and that the phosphate groups of the assembled nucleotides can facilitate nucleation of a second hydroxyapatite crystal. This would provide a mechanism of replication that is subject to natural selection. The possible role of a replicating system of this kind in the origins of life on the… CONTINUE READING

Figures and Topics from this paper.

Explore Further: Topics Discussed in This Paper

References

Publications referenced by this paper.
SHOWING 1-4 OF 4 REFERENCES

Origins - A Skeptics Guide to the Creation o f Life on Earth, Summit Books

L. E. York. Orgel
  • J. Theor. Biol.,
  • 1986
VIEW 1 EXCERPT

On the Possible Role o f Crystals in the Origins o f Life, AEC

S. M. Krane, M. J. Glimcher
  • J. Biological Chem
  • 1984