Dictyostelium discoideum mutants with temperature-sensitive defects in endocytosis

@article{Bacon1994DictyosteliumDM,
  title={Dictyostelium discoideum mutants with temperature-sensitive defects in endocytosis},
  author={R A Bacon and Cyril J. Cohen and David A. Lewin and Ira Mellman},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={127},
  pages={387 - 399}
}
We have isolated and characterized temperature-sensitive endocytosis mutants in Dictyostelium discoideum. Dictyostelium is an attractive model for genetic studies of endocytosis because of its high rates of endocytosis, its reliance on endocytosis for nutrient uptake, and tractable molecular genetics. Endocytosis-defective mutants were isolated by a fluorescence-activated cell sorting (FACS) as cells unable to take up a fluorescent marker. One temperature-sensitive mutant (indy1) was… CONTINUE READING

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