Dictyostelium discoideum Sir2D modulates cell-type specific gene expression and is involved in autophagy.

@article{Lohia2017DictyosteliumDS,
  title={Dictyostelium discoideum Sir2D modulates cell-type specific gene expression and is involved in autophagy.},
  author={Rakhee Lohia and Punita Jain and Mukul Jain and Pradeep Kumar Burma and Anju Shrivastava and Shweta Saran},
  journal={The International journal of developmental biology},
  year={2017},
  volume={61 1-2},
  pages={
          95-104
        }
}
Sirtuins (SIRTs) belong to class III histone deacetylases and require NAD+ for their activity. Their activity is associated with the nutritional status of the cell and they directly link cellular metabolic signalling to the state of protein post-translational modifications. Sirtuins play an important role in healthy aging, longevity and age-related diseases, as well as in cell survival mechanisms, such as autophagy. Here, we investigate the functions of Dictyostelium discoideum Sir2D which… CONTINUE READING

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