Dictyostelium discoideum: a useful model system to evaluate the function of queuine and of the Q‐family of tRNAs

@article{Ott1982DictyosteliumDA,
  title={Dictyostelium discoideum: a useful model system to evaluate the function of queuine and of the Q‐family of tRNAs},
  author={G. Ott and H. Kersten and S. Nishimura},
  journal={FEBS Letters},
  year={1982},
  volume={146}
}
The nucleoside queuosine (Q) is found in the first position of the anticodon of tRNATy r, tRNA His, tRNAAsp and tRNA Asn of eubacteria and eukaryotes except yeast [1]. In eukaryotes queuine is inserted into the tRNAs in exchange for guanine by the enzyme queuine: guanine tRNAtransglycosylase [2,3]. Experiments with germ-free mice, fed on queuine-free diet, showed that mice do not synthesize queuine de novo [4,5]. The modification queuine in the Q-family of tRNA was found to be incomplete in… Expand
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