Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.

@article{TakahashiYanaga2003DictyosteliumDF,
  title={Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells.},
  author={Fumi Takahashi-Yanaga and Yoji Taba and Yoshikazu Miwa and Yuzuru Kubohara and Yutaka Watanabe and Masato Hirata and Sachio Morimoto and Toshiyuki Sasaguri},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 11},
  pages={9663-70}
}
In search of chemical substances applicable for the treatment of cancer and other proliferative disorders, we studied the signal transduction of Dictyostelium differentiation-inducing factors (DIFs) in mammalian cells mainly using HeLa cells. Although DIF-1 and DIF-3 both strongly inhibited cell proliferation by inducing G(0)/G(1) arrest, DIF-3 was more effective than DIF-1. DIF-3 suppressed cyclin D1 expression at both mRNA and protein levels, whereas the overexpression of cyclin D1 overrode… CONTINUE READING

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