Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells.

@article{Omata2007DictyosteliumDF,
  title={Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells.},
  author={Waka Omata and Hiroshi Shibata and Masahiro Nagasawa and Itaru Kojima and Haruhisa Kikuchi and Yoshiteru Oshima and Kohei Hosaka and Yuzuru Kubohara},
  journal={The FEBS journal},
  year={2007},
  volume={274 13},
  pages={
          3392-404
        }
}
The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell formation in the cellular slime mold Dictyostelium discoideum, while DIF-1 and its analogs have been shown to possess antiproliferative activity in vitro in mammalian tumor cells. In the present study, we investigated the effects of DIF-1 and its analogs on normal (nontransformed) mammalian cells. Without affecting the cell morphology and cell number, DIF-1 at micromolar levels dose-dependently promoted… CONTINUE READING
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