Dictyostelium PAKc is required for proper chemotaxis.

  title={Dictyostelium PAKc is required for proper chemotaxis.},
  author={Susan Lee and Francisco Rivero and Kyung Chan Park and Emerald Huang and Satoru Funamoto and Richard A. Firtel},
  journal={Molecular biology of the cell},
  volume={15 12},
We have identified a new Dictyostelium p21-activated protein kinase, PAKc, that we demonstrate to be required for proper chemotaxis. PAKc contains a Rac-GTPase binding (CRIB) and autoinhibitory domain, a PAK-related kinase domain, an N-terminal phosphatidylinositol binding domain, and a C-terminal extension related to the Gbetagamma binding domain of Saccharomyces cerevisiae Ste20, the latter two domains being required for PAKc transient localization to the plasma membrane. In response to… CONTINUE READING
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