Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamics.

@article{Rehberg2005DictyosteliumLI,
  title={Dictyostelium LIS1 is a centrosomal protein required for microtubule/cell cortex interactions, nucleus/centrosome linkage, and actin dynamics.},
  author={Markus Rehberg and Julia Kleylein-Sohn and Jan Faix and Ting Nong Ho and Irene J. Schulz and Ralph O Gr{\"a}f},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 6},
  pages={
          2759-71
        }
}
The widespread LIS1-proteins were originally identified as the target for sporadic mutations causing lissencephaly in humans. Dictyostelium LIS1 (DdLIS1) is a microtubule-associated protein exhibiting 53% identity to human LIS1. It colocalizes with dynein at isolated, microtubule-free centrosomes, suggesting that both are integral centrosomal components. Replacement of the DdLIS1 gene by the hypomorphic D327H allele or overexpression of an MBP-DdLIS1 fusion disrupted various dynein-associated… CONTINUE READING
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