Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis

@article{Adachi1997DictyosteliumIP,
  title={Dictyostelium IQGAP-related Protein Specifically Involved in the Completion of Cytokinesis},
  author={Hiroyuki Adachi and Yasuhiro Takahashi and Takeshi Hasebe and Mikako Shirouzu and Shigeyuki Yokoyama and Kazuo Sutoh},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={891 - 898}
}
The gapA gene encoding a novel RasGTPase-activating protein (RasGAP)-related protein was found to be disrupted in a cytokinesis mutant of Dictyostelium that grows as giant and multinucleate cells in a dish culture. The predicted sequence of the GAPA protein showed considerable homology to those of Gap1/Sar1 from fission yeast and the COOH-terminal half of mammalian IQGAPs, the similarity extending beyond the RasGAP-related domain. In suspension culture, gapA- cells showed normal growth in terms… CONTINUE READING
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