Dictyostelium Extracellular Vesicles Containing Hoechst 33342 Transfer the Dye into the Nuclei of Living Cells: A Fluorescence Study

@article{Tatischeff2007DictyosteliumEV,
  title={Dictyostelium Extracellular Vesicles Containing Hoechst 33342 Transfer the Dye into the Nuclei of Living Cells: A Fluorescence Study},
  author={Ir{\`e}ne Tatischeff and Françoise Lavialle and Sophie Pigaglio-Deshayes and Christine P{\'e}choux-Longin and Laurent Chinsky and Annette Alfsen},
  journal={Journal of Fluorescence},
  year={2007},
  volume={18},
  pages={319-328}
}
Cells of the eukaryotic unicellular microorganism Dictyostelium discoideum are constitutively resistant to vital staining of their nuclei by the DNA-specific dye Hoechst 33342. By studying the mechanisms of this resistance, we evidenced that these cells expel vesicles containing the dye for detoxification (Tatischeff et al., Cell Mol Life Sci, 54: 476–87, 1998). The question to be addressed in the present work is the potential use of these extracellular vesicles as a biological drug delivery… CONTINUE READING
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