Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction.

@article{Naidoo2009DiclofenacTI,
  title={Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction.},
  author={Vinasan Naidoo and Gerry E Swan},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2009},
  volume={149 3},
  pages={269-74}
}
Diclofenac (DF), a non-steroidal anti-inflammatory drug (NSAID), is largely regarded as one of the most devastating environmental toxicant in recent times, after accidental exposure via their food-chain lead to massive mortalities in three vulture species on the Asian subcontinent. Although the use of diclofenac was recently banned on the Indian subcontinent, following the favourable safety profile of meloxicam, its mechanism of toxicity remains unknown. In an attempt to establish this… CONTINUE READING