Diclofenac sodium, a nonselective nonsteroidal anti-inflammatory drug aggravates doxorubicin-induced cardiomyopathy in rats.

@article{Singh2010DiclofenacSA,
  title={Diclofenac sodium, a nonselective nonsteroidal anti-inflammatory drug aggravates doxorubicin-induced cardiomyopathy in rats.},
  author={Bhulan Kumar Singh and Rahila Ahmad Pathan and Krishna Kolappa Pillai and Syed Ehtaishamul Haque and Kiran Dubey},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={55 2},
  pages={139-44}
}
The cardiotoxic effects of selective cyclo-oxygenase-2 inhibitors are well documented. Recently, concerns have been raised over the cardiovascular safety of nonselective nonsteroidal antiinflammatory drugs. The aim of this study was to assess the cardiac effects of diclofenac sodium on doxorubicin-induced cardiomyopathy in rats. Male Wistar rats were… CONTINUE READING