Diclofenac: an update on its mechanism of action and safety profile

@article{Gan2010DiclofenacAU,
  title={Diclofenac: an update on its mechanism of action and safety profile},
  author={Tong J. Gan},
  journal={Current Medical Research and Opinion},
  year={2010},
  volume={26},
  pages={1715 - 1731}
}
  • T. Gan
  • Published 15 June 2010
  • Medicine
  • Current Medical Research and Opinion
BACKGROUND Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. [] Key Method Reference citations resulting from publications identified in the literature search were reviewed when appropriate. METHODS This article reviews the established, putative, and emerging MOAs of diclofenac; compares the…
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Severe anaphylactic reaction to diclofenac.
Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats
TLDR
Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, can lead to adverse effects on the gastrointestinal tract and the kidney, where the latter is partly due to reduced renal blood flow causing ischemia and subsequent necrosis.
Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis
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A systematic review to evaluate the analgesic activity of compounds complexed in cyclodextrins, analyzing whether these complexes improved analgesic efficacy found that the complexed drug had a significantly (p < 0.01) greater effect than the non-complexed drug.
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