Diclofenac: an update on its mechanism of action and safety profile

@article{Gan2010DiclofenacAU,
  title={Diclofenac: an update on its mechanism of action and safety profile},
  author={Tong J. Gan},
  journal={Current Medical Research and Opinion},
  year={2010},
  volume={26},
  pages={1715 - 1731}
}
  • T. Gan
  • Published 15 June 2010
  • Medicine
  • Current Medical Research and Opinion
BACKGROUND Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. [] Key Method Reference citations resulting from publications identified in the literature search were reviewed when appropriate. METHODS This article reviews the established, putative, and emerging MOAs of diclofenac; compares the…
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359 Citations
Highly Influential Citations
19
Background Citations
142
Methods Citations
11
Results Citations
2

359 Citations

Advances in NSAID Development: Evolution of Diclofenac Products Using Pharmaceutical Technology
TLDR
How pharmaceutical technology has been used to modify the pharmacokinetic properties of diclofenac, leading to the creation of novel drug products with improved clinical utility is illustrated.
A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials
  • K. Pavelka
  • Medicine
    Current medical research and opinion
  • 2012
TLDR
The efficacy of diclofenac is largely unchallenged in that it remains as effective as newer pain relief medications employed in OA.
Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome
  • R. Barkin
  • Medicine, Biology
    American journal of therapeutics
  • 2015
TLDR
It is important to recognize that pharmacokinetic absorption from topical formulations can vary markedly, even between different formulations of the same drug, depending on the agent, the underlying disorder, and the site of application, and it is essential to consider the patient, the drug, andThe drug delivery mechanism when selecting a topical NSAID preparation.
Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
TLDR
The case is made for further clinical investigation of the anticancer effects of DCF, particularly in combination with other agents - with a range of possible multi-drug and multi-modality combinations outlined in the supplementary materials accompanying the main paper.
Efficacy and Safety Profile of Diclofenac/Cyclodextrin and Progesterone/Cyclodextrin Formulations: A Review of the Literature Data
TLDR
The newly approved lower dose of diclofenac associated with cyclodextrins is consistent with the European Medicines Agency recommendations reported in the revision of the Assessment Report for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Cardiovascular Risk.
Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review
TLDR
Topical NSAIDs such as diclofenac should be considered as a guideline-supported, generally well-tolerated, and effective first-line treatment option for knee and hand OA, especially for older patients and those who have comorbid conditions and/or risk factors for various systemic adverse events associated with oral NSAIDs.
Severe anaphylactic reaction to diclofenac.
Anti-inflammatory and analgesic potential of OA-DHZ; a novel semisynthetic derivative of dehydrozingerone.
Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats
TLDR
Non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, can lead to adverse effects on the gastrointestinal tract and the kidney, where the latter is partly due to reduced renal blood flow causing ischemia and subsequent necrosis.
Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis
TLDR
A systematic review to evaluate the analgesic activity of compounds complexed in cyclodextrins, analyzing whether these complexes improved analgesic efficacy found that the complexed drug had a significantly (p < 0.01) greater effect than the non-complexed drug.
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