Dickkopf-related protein 3 promotes pathogenic stromal remodeling in benign prostatic hyperplasia and prostate cancer

@inproceedings{Zenzmaier2013DickkopfrelatedP3,
  title={Dickkopf-related protein 3 promotes pathogenic stromal remodeling in benign prostatic hyperplasia and prostate cancer},
  author={Christoph Zenzmaier and Natalie Sampson and Eugen G. Plas and Peter Berger},
  booktitle={The Prostate},
  year={2013}
}
BACKGROUND Compartment-specific epithelial and stromal expression of the secreted glycoprotein Dickkopf-related protein (Dkk)-3 is altered in age-related proliferative disorders of the human prostate. This study aimed to determine the effect of Dkk-3 on prostate stromal remodeling that is stromal proliferation, fibroblast-to-myofibroblast differentiation and expression of angiogenic factors in vitro. METHODS Lentiviral-delivered overexpression and shRNA-mediated knockdown of DKK3 were applied… CONTINUE READING

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