Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis.

@article{Pfaff2011DickkopfPI,
  title={Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis.},
  author={E-M Pfaff and Simone Becker and Andreas G{\"u}nther and Melanie K{\"o}nigshoff},
  journal={The European respiratory journal},
  year={2011},
  volume={37 1},
  pages={79-87}
}
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with unknown pathogenesis. The WNT/β-catenin pathway has recently been reported to be operative in epithelial cells in IPF. Dickkopf (DKK) proteins are known to regulate WNT signalling via interaction with Kremen (KRM) receptors, yet their expression and role in the adult lung and in IPF has not been addressed. We analysed the expression, localisation and function of DKK and KRM proteins in IPF lungs using Western blotting… CONTINUE READING
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