Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.

@article{Romero2016Dickkopf3RP,
  title={Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases.},
  author={Diana Mar{\'i}a Carlos Romero and Zainab Al-Shareef and Irantzu Gorro{\~n}o-Etxebarria and Stephanie Atkins and Frances Turrell and Jyoti B. Chhetri and Nora Bengoa-Vergniory and Christoph Zenzmaier and Peter Berger and Jonathan A. Waxman and Robert M Kypta},
  journal={Carcinogenesis},
  year={2016},
  volume={37 1},
  pages={
          18-29
        }
}
Dickkopf-3 (Dkk-3) is a secreted protein whose expression is downregulated in many types of cancer. Endogenous Dkk-3 is required for formation of acini in 3D cultures of prostate epithelial cells, where it inhibits transforming growth factor (TGF)-β/Smad signaling. Here, we examined the effects of Dkk-3 on the expression and activity of matrix metalloproteases (MMPs), which mediate the effects of TGF-β on extracellular matrix disassembly during tissue morphogenesis and promote invasion of tumor… CONTINUE READING
2
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1

Zainab Al Shareef, Hoda Kardooni, +9 authors Robert M. Kypta
  • Oncogene
  • 2018
VIEW 19 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3.

  • Biochimica et biophysica acta
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.

  • Molecular and cellular biology
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of prostate cell growth and morphogenesis

Y Kawano
  • by Dickkopf-3. Oncogene,
  • 2006
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL