Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter.

@article{Paulis2002DicinnamoylquinidesIR,
  title={Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter.},
  author={Tomas de Paulis and Dennis E. Schmidt and Aleksandra Krsmanović Bruchey and Michael T Kirby and Michael P. McDonald and Patricia A. Commers and David M. Lovinger and Peter R. Martin},
  journal={European journal of pharmacology},
  year={2002},
  volume={442 3},
  pages={
          215-23
        }
}
Preliminary screening of a minor, non-xanthine constituent of roasted coffee, 3,4-diferuloyl-1,5-quinolactone (DIFEQ), showed inhibition of the adenosine transporter at low micromolar concentration. DIFEQ is a neutral derivative of the chlorogenic acids, i.e. isomeric mono- and di-substituted coumaroyl-, caffeoyl-, and feruloyl-esters of quinic acid, formed in the roasting process of coffee. Displacement of the adenosine transporter antagonist [(3)H](S)-(nitrobenzyl)-6-thioinosine binding by… CONTINUE READING
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