Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.

@article{Kater2002DichotomalEO,
  title={Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction.},
  author={Arnon P Kater and Maikel P Peppelenbosch and Desiderius P. M. Brandjes and Mika Lumbantobing},
  journal={Clinical and diagnostic laboratory immunology},
  year={2002},
  volume={9 6},
  pages={1396-7}
}
Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin. 

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