Dichloroacetic acid and trichloroacetic acid-induced DNA strand breaks are independent of peroxisome proliferation.

@article{Nelson1989DichloroaceticAA,
  title={Dichloroacetic acid and trichloroacetic acid-induced DNA strand breaks are independent of peroxisome proliferation.},
  author={Mark A. Nelson and A J Lansing and Idalia M. Sanchez and Richard J. Bull and D. L. Springer},
  journal={Toxicology},
  year={1989},
  volume={58 3},
  pages={239-48}
}
This study examined whether the induction of single strand breaks in hepatic DNA by dichloroacetic acid (DCA) and trichloroacetic acid (TCA) depends upon peroxisome proliferation. Male B6C3F1 mice were given a single oral dose of either DCA or TCA. At varying times, between 1 and 24 h after administration of the compounds, breaks in DNA were measured using an alkaline unwinding assay. Peroxisome proliferation was monitored at the same time intervals in a parallel experiment by measuring… CONTINUE READING

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