Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer

@article{Garon2014DichloroacetateSB,
  title={Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer},
  author={Edward B. Garon and Heather R Christofk and Wylie D Hosmer and Carolyn D. Britten and Agnes Y. Bahng and Matthew J. Crabtree and Candice Sun Hong and Naeimeh Kamranpour and Sharon A. Pitts and Fairooz F. Kabbinavar and Cecil Patel and Erika von Euw and Alexander Black and Evangelos D Michelakis and Steven Dubinett and Dennis J. Slamon},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2014},
  volume={140},
  pages={443-452}
}
Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic phenotype in preclinical cancer studies. We designed this open-label phase II trial to determine the response rate, safety, and tolerability of oral DCA in patients with metastatic breast cancer and advanced stage non-small cell lung cancer (NSCLC). This trial was conducted with DCA 6.25 mg/kg orally twice daily in previously treated… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
23 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Carbohydrate metabolism I : Anaerobic processes in generating metabolic energy

  • CK Mathews, Holde Kv, KG Ahern
  • 2000
Highly Influential
10 Excerpts

Electron transport , oxidative phosphorylation , and oxygen metabolism

  • CK Mathews, Holde Kv, KG Ahern
  • Biochemistry
  • 2000
Highly Influential
10 Excerpts

Antiestrogen fulvestrant

  • EB Garon, RJ Pietras, RS Finn
  • growth. Mol Cancer Ther
  • 2013
3 Excerpts

Similar Papers

Loading similar papers…