Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

@article{Madhok2010DichloroacetateIA,
  title={Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells},
  author={Brijesh Madanmohan Madhok and Sashidhar Yeluri and Sarah L Perry and Tom Hughes and David G. Jayne},
  journal={British Journal of Cancer},
  year={2010},
  volume={102},
  pages={1746 - 1752}
}
Background:Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms.Methods:Representative colorectal cancer and non-cancerous cell lines were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase.Results:Dichloroacetate (20 mM) did not reduce growth of non… CONTINUE READING
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