Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

  title={Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells},
  author={Brijesh Madanmohan Madhok and Sashidhar Yeluri and Sarah L Perry and Tom Hughes and David G. Jayne},
  journal={British Journal of Cancer},
  pages={1746 - 1752}
Background:Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer cells over normal cells, and to examine the underlying mechanisms.Methods:Representative colorectal cancer and non-cancerous cell lines were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase.Results:Dichloroacetate (20 mM) did not reduce growth of non… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
68 Extracted Citations
29 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 68 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 29 references

perfused rat heart by dichloroacetate

  • JY Wong, GS Huggins, M Debidda, NC Munshi, I De Vivo
  • Biochem J 134:
  • 2008
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…