Dichloroacetate-induced changes in liver of normal and diabetic rats.

@article{Anderson1975DichloroacetateinducedCI,
  title={Dichloroacetate-induced changes in liver of normal and diabetic rats.},
  author={James W. Anderson and Dennis G. Karounos and Takashi Yoneyama and J. William Hollingsworth},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1975},
  volume={149 3},
  pages={814-21}
}
Dichloroacetate (DCA) was administered orally to normal (nondiabetic) and streptozotocin-diabetic rats in a dose of 1000 mg/day/kg rat wt. One group of diabetic animals received DCA both orally and intraperitoneally. DCA therapy lowered the blood glucose values of diabetic animals but did not alter values in nondiabetic rats. The hepatic activity of glucokinase and pyruvate kinase were significantly lower in both DCA-treated nondiabetic and DCA-treated diabetic animals than values observed for… CONTINUE READING
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