Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.

Abstract

Dichloroacetate (DCA) stimulates pyruvate dehydrogenase complex (PDHC) activity and lowers cerebral lactate concentrations. In the R6/2 and N171-82Q transgenic mouse models of Huntington's disease (HD), DCA significantly increased survival, improved motor function, delayed loss of body weight, attenuated the development of striatal neuron atrophy, and… (More)

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Cite this paper

@article{Andreassen2001DichloroacetateET, title={Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.}, author={Ole A. Andreassen and Robert Ferrante and Han Ming Huang and Alpaslan Dedeoglu and Larry C H Park and Kimberly L Ferrante and Jeanie Kwon and David R Borchelt and Christopher A. Ross and Gary E Gibson and Myron Flint Beal}, journal={Annals of neurology}, year={2001}, volume={50 1}, pages={112-7} }