Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a

@article{Nesterova2008DicerRX,
  title={Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a},
  author={Tatyana B. Nesterova and Bilyana C Popova and Bradley S Cobb and Sara Norton and Claire E. Senner and Y. Amy Tang and Thomas Spruce and Tristan A Rodr{\'i}guez and Takashi Sado and Matthias Merkenschlager and Neil Brockdorff},
  journal={Epigenetics & Chromatin},
  year={2008},
  volume={1},
  pages={2 - 2}
}
X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis by expression of the non-coding RNA Xist. As such, correct regulation of the Xist gene promoter is required to establish appropriate X chromosome activity both in males and females. Studies to date have demonstrated co-transcription of an antisense RNA Tsix and low-level sense transcription prior to onset of X… CONTINUE READING