Dicer recognizes the 5′ end of RNA for efficient and accurate processing

@article{Park2011DicerRT,
  title={Dicer recognizes the 5′ end of RNA for efficient and accurate processing},
  author={Jong-Eun Park and Inha Heo and Yuan Tian and Dhirendra Kumar Simanshu and Hyeshik Chang and David Jee and Dinshaw J. Patel and V. Narry Kim},
  journal={Nature},
  year={2011},
  volume={475},
  pages={201-205}
}
A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing by Dicer is crucial for the functionality of microRNAs (miRNAs). The current model posits that Dicer selects cleavage sites by measuring a set distance from the 3′ overhang of the double-stranded RNA… CONTINUE READING