Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro.

@article{Wu2012DicermicroRNAPI,
  title={Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro.},
  author={Di Wu and Abdalla Raafat and Elena S. Pak and Stefan Clemens and Alexander K. Murashov},
  journal={Experimental neurology},
  year={2012},
  volume={233 1},
  pages={555-65}
}
Both central and peripheral axons contain pivotal microRNA (miRNA) proteins. While recent observations demonstrated that miRNA biosynthetic machinery responds to peripheral nerve lesion in an injury-regulated pattern, the physiological significance of this phenomenon remains to be elucidated. In the current paper we hypothesized that deletion of Dicer would disrupt production of Dicer-dependent miRNAs and would negatively impact regenerative axon growth. Taking advantage of tamoxifen-inducible… CONTINUE READING

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