Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.

@article{Damiani2008DicerIL,
  title={Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina.},
  author={Devid Damiani and John J. Alexander and Jason R O'Rourke and Michael G. McManus and A P Jadhav and Constance L. Cepko and William W. Hauswirth and Brian D Harfe and Enrica Strettoi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 19},
  pages={
          4878-87
        }
}
MicroRNAs (miRNAs) are small, highly conserved molecules that have been shown to regulate the expression of genes by binding to specific target mRNAs. Dicer, an RNase III endonuclease, is essential for the production and function of mature miRNAs, and removal of Dicer has been shown to disrupt many developmental processes. In this study, Dicer was removed specifically from the retina using a floxed Dicer conditional allele and the retinal Chx10Cre transgene. Retinal Dicer knock-out mice… CONTINUE READING
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