Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.

@article{Ketting2001DicerFI,
  title={Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.},
  author={Ren{\'e} F Ketting and Sylvia E. J. Fischer and Elizabeth Bernstein and Titia Sijen and Gregory J Hannon and Ronald H. A. Plasterk},
  journal={Genes & development},
  year={2001},
  volume={15 20},
  pages={2654-9}
}
Double-stranded RNAs can suppress expression of homologous genes through an evolutionarily conserved process named RNA interference (RNAi) or post-transcriptional gene silencing (PTGS). One mechanism underlying silencing is degradation of target mRNAs by an RNP complex, which contains approximately 22 nt of siRNAs as guides to substrate selection. A bidentate nuclease called Dicer has been implicated as the protein responsible for siRNA production. Here we characterize the Caenorhabditis… CONTINUE READING
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