Dicer function is required in the metanephric mesenchyme for early kidney development.

Abstract

MicroRNAs (miRNAs) are small, noncoding regulatory RNAs that act as posttranscriptional repressors by binding to the 3'-untranslated region (3'-UTR) of target genes. They require processing by Dicer, an RNase III enzyme, to become mature regulatory RNAs. Previous work from our laboratory revealed critical roles for miRNAs in nephron progenitors at… (More)
DOI: 10.1152/ajprenal.00426.2013

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