Dicer expression and localization in post-mitotic neurons.

  title={Dicer expression and localization in post-mitotic neurons.},
  author={Christian Barbato and Maria Teresa Ciotti and Annalucia Serafino and Pietro Calissano and Carlo Cogoni},
  journal={Brain research},
RNA-mediated gene silencing is recently emerged as a fundamental mechanism of regulation of gene expression in many organisms and tissues, with special emphasis with respect to the nervous system. With the aim to study the components of RNA silencing machinery, we have investigated the expression profile and localization of dicer protein RNase III endonuclease in cultures of post-mitotic neurons. Dicer catalyzes the processing of double-stranded RNAs (dsRNAs) into approximately 21-25 nucleotide… CONTINUE READING


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