Dicentric chromosomes and the inactivation of the centromere

  title={Dicentric chromosomes and the inactivation of the centromere},
  author={Eeva Therman and Carolyn Trunca and Evelyn Meyer Kuhn and Gloria E. Sarto},
  journal={Human Genetics},
The origin and behavior of human dicentric chromosomes are reviewed. Most dicentrics between two non-homologous or two homologous chromosomes (isodicentrics), which are permanent members of a chromosome complement, probably originate from segregation of an adjacent quadriradial; such configurations are the result of a chromatid translocation between two nonhomologous chromosomes, or they represent an adjacent counterpart of a mitotic chiasma. The segregation of such a quadriradial may also give… CONTINUE READING

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Human chromosomes, structure, behavior, effects, 2nd edn

E Therman
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Isodicentric X chromosomes in humans : origin , segregation behavior , and replication band patterns

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