Dibromoacetic acid affects reproductive competence and sperm quality in the male rat.

@article{Linder1995DibromoaceticAA,
  title={Dibromoacetic acid affects reproductive competence and sperm quality in the male rat.},
  author={R E Linder and Gary Robert Klinefelter and Lillian F. Strader and Michael G. Narotsky and Juan D. Suarez and Naomi L Roberts and Sally D. Perreault},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1995},
  volume={28 1},
  pages={9-17}
}
Recently, we demonstrated with short-duration tests that dibromoacetic acid (DBAA), a commonly occurring by-product of water disinfection, alters sperm morphology and motility in the male rat. These results suggested that the effects of DBAA on sperm quality were likely to compromise reproductive competence of the male rat early in subchronic exposure. The present studies were undertaken to investigate the dose response and time course of alterations in fertility and sperm quality. Proven… CONTINUE READING

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However , these males remained fertile , litter size was unaffected , and no paternally mediated developmental defects were noted in their offspring .
However , these males remained fertile , litter size was unaffected , and no paternally mediated developmental defects were noted in their offspring .
Exposure to 50 mg / kg resulted in moderate changes in sperm morphology and motility and moderate decreases in epididymal sperm counts in rats dosed for 31 or 79 days .
Exposure to 50 mg / kg resulted in moderate changes in sperm morphology and motility and moderate decreases in epididymal sperm counts in rats dosed for 31 or 79 days .
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