Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy.

@article{Li2007DiblockCM,
  title={Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy.},
  author={Buhong Li and Eduardo H. Moriyama and Fugang Li and Mark T Jarvi and Christine Allen and Brian C. Wilson},
  journal={Photochemistry and photobiology},
  year={2007},
  volume={83 6},
  pages={1505-12}
}
Polymeric micelles are emerging as an effective drug delivery system for hydrophobic photosensitizers in photodynamic therapy (PDT). The objective of this study was to investigate the formulation of hydrophobic protoporphyrin IX (PpIX) with MePEG(5000)-b-PCL(4100) [methoxy poly (ethylene glycol)-b-poly (caprolactone)] diblock copolymers and to compare their PDT response to that of free PpIX. The photophysical and photochemical properties of the polymeric PpIX micelles were studied by measuring… CONTINUE READING
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