Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein

  title={Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein},
  author={Qiangrong Pan and Qinghua Lu and Kun Zhang and Xun Hu},
  journal={Cancer Chemotherapy and Pharmacology},
Purpose: To determine if five dibenzocyclooctadiene lingnans, a class of naturally occurring compounds from Schisandra chinensis (Turcz.) Baill, have the activities to reverse P-glycoprotein (P-gp) mediated multidrug resistance (MDR). Methods: The IC50s of four MDR cell lines (K562/Adr, MCF-7/Adr, KBv200, and Bcap37/Adr) toward daunorubicin, vincristine, and paclitaxel in the presence or absence of one of the dibenzocyclooctadiene lingnans were determined by a FACscan assay. The intracellular… CONTINUE READING


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