Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1.

@article{Li2007DibenzocyclooctadieneLA,
  title={Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1.},
  author={Ling Li and Qiangrong Pan and Meng Sun and Qinghua Lu and Xun Hu},
  journal={Life sciences},
  year={2007},
  volume={80 8},
  pages={741-8}
}
We recently reported that dibenzocyclooctadiene lignans were a novel class of P-glycoprotein (P-gp) inhibitors. In this study, we demonstrated that the lignans of this class were also effective inhibitors of multidrug resistance-associated protein 1 (MRP1). The activities of 5 dibenzocyclooctadiene lignans (schisandrin A, schisandrin B, schisantherin A, schisandrol A, and schisandrol B) to reverse MRP1-mediated drug resistance were tested using HL60/Adriamycin (ADR) and HL60/Multidrug… CONTINUE READING

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