Diazoxide Reduces Status Epilepticus Neuron Damage in Diabetes

@article{Huang2009DiazoxideRS,
  title={Diazoxide Reduces Status Epilepticus Neuron Damage in Diabetes},
  author={Chin-Wei Huang and Sheng-Nan Wu and Juei-Tang Cheng and Jing-Jane Tsai and Chao-Ching Huang},
  journal={Neurotoxicity Research},
  year={2009},
  volume={17},
  pages={305-316}
}
Diabetic hyperglycemia is associated with seizure severity and may aggravate brain damage after status epilepticus. Our earlier studies suggest the involvement of ATP-sensitive potassium channels (KATP) in glucose-related neuroexcitability. We aimed to determine whether KATP agonist protects against status epilepticus-induced brain damage. Adult male Sprague–Dawley rats were divided into two groups: the streptozotocin (STZ)-induced diabetes (STZ) group and the normal saline (NS) group. Both… CONTINUE READING
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