Diazinon is activated by CYP2C19 in human liver.

@article{Kappers2001DiazinonIA,
  title={Diazinon is activated by CYP2C19 in human liver.},
  author={Willemijn Kappers and Robert J Edwards and Stephen G. Murray and Alan R Boobis},
  journal={Toxicology and applied pharmacology},
  year={2001},
  volume={177 1},
  pages={
          68-76
        }
}
Phosphorothioate compounds are used throughout the world as agricultural and domestic pesticides. Here, the activation of the phosphorothioate diazinon to diazoxon in human liver is described. In an initial study using three human liver microsomal samples, K(m) for diazoxon formation varied markedly (31, 208, and 660 microM; V(max) 1125, 685, and 1028 pmol/min/mg protein, respectively), suggesting the involvement of more than one P450 enzyme. A wide variation in activity was found using 50… CONTINUE READING

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