Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia.

@article{Galeffi2000DiazepamPA,
  title={Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia.},
  author={Francesca Galeffi and Shamim A. Sinnar and Rochelle D. Schwartz-Bloom},
  journal={Journal of neurochemistry},
  year={2000},
  volume={75 3},
  pages={1242-9}
}
Benzodiazepines protect hippocampal neurons when administered within the first few hours after transient cerebral ischemia. Here, we examined the ability of diazepam to prevent early signals of cell injury (before cell death) after in vitro ischemia. Ischemia in vitro or in vivo causes a rapid depletion of ATP and the generation of cell death signals, such as the release of cytochrome c from mitochondria. Hippocampal slices from adult rats were subjected to 7 min of oxygen-glucose deprivation… CONTINUE READING

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