Diazepam blocks striatal lipid peroxidation and improves stereotyped activity in a rat model of acute stress.

@article{MndezCuesta2011DiazepamBS,
  title={Diazepam blocks striatal lipid peroxidation and improves stereotyped activity in a rat model of acute stress.},
  author={Luis Alejandro M{\'e}ndez-Cuesta and Berenice M{\'a}rquez-Valadez and Ver{\'o}nica P{\'e}rez-de la Cruz and Carolina Escobar-Briones and Sonia Galv{\'a}n-Arzate and Yarummy {\'A}lvarez-Ru{\'i}z and Perla D Maldonado and Ricardo A Santana and Abel Santamar{\'i}a and Paul Carrillo-Mora},
  journal={Basic & clinical pharmacology & toxicology},
  year={2011},
  volume={109 5},
  pages={350-6}
}
In this work, the effect of a single dose of diazepam was tested on different markers of oxidative damage in the striatum of rats in an acute model of immobilization (restraint) stress. In addition, the locomotor activity was measured at the end of the restraint period. Immobilization was induced to animals for 24 hr, and then, lipid peroxidation, superoxide dismutase activity and content, and mitochondrial function were all estimated in striatal tissue samples. Corticosterone levels were… CONTINUE READING