Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function.

@article{Cosentino2000DiazepambindingIP,
  title={Diazepam-binding inhibitor-derived peptides induce intracellular calcium changes and modulate human neutrophil function.},
  author={Marco Cosentino and Franca Marino and Simona Cattaneo and L Di Grazia and C Francioli and Anna Maria Fietta and Sergio Lecchini and Gian Mario Frigo},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={67 5},
  pages={637-43}
}
We studied the effects of two diazepam-binding inhibitor (DBI)-derived peptides, triakontatetraneuropeptide (DBI 17-50, TTN) and eiksoneuropeptide (DBI 51-70, ENP), on cytosolic free Ca2+ concentrations ([Ca2+]i), chemotaxis, superoxide anion (O2-) generation, and phagocytosis in human neutrophils. Both TTN and ENP induced a rapid and transient rise of [Ca2+]i. The effect of TTN depended on the presence of extracellular Ca2+, whereas the effect of ENP also persisted after extracellular Ca2… CONTINUE READING
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