Diazepam and desmethyldiazepam plasma concentrations in chronic anxious outpatients.

@article{Rickels1984DiazepamAD,
  title={Diazepam and desmethyldiazepam plasma concentrations in chronic anxious outpatients.},
  author={Karl E. Rickels and Warren G. Case and Robert W. Downing and Ross Dixon and R B Fridman},
  journal={Pharmacopsychiatry},
  year={1984},
  volume={17 2},
  pages={
          44-9
        }
}
Within the framework of a large-scale clinical study on the effect of diazepam in chronic anxiety, diazepam (D) and desmethyldiazepam (DD) plasma concentrations were determined frequently. Significant relationships were found between the clinical effect and the plasma concentrations of D and DD, respectively; a curvilinear relationship resulted if the dosage was disregarded, but within the individual dosage groups the relationship was found to be linear. For these computations, the daily… Expand
Bestimmung der Pharmakokinetik verschiedener Benzodiazepine mit Hilfe einer Rezeptorbindungsmethode
TLDR
Für die Beantwortung spezieller Fragestellungen müssen aber nach wie vor Chromatographische Methoden zur Bestimmung von Benzodiazepinen and ihren aktiven Metaboliten verwendet werden. Expand