Diazepam action onγ-aminobutyric acid-activated chloride currents in internally perfused frog sensory neurons

@article{Hattori1986DiazepamAO,
  title={Diazepam action onγ-aminobutyric acid-activated chloride currents in internally perfused frog sensory neurons},
  author={Kiichi Hattori and Yutaka Oomura and Norio Akaike},
  journal={Cellular and Molecular Neurobiology},
  year={1986},
  volume={6},
  pages={307-323}
}
1. The Cl− current (I Cl) inγ-aminobutyric acid (GABA)-sensitive frog sensory neuron was separated from other Na+, Ca2+, and K+ currents using a suction pipette technique which allows internal perfusion under a single-electrode voltage clamp. 2. Diazepam (DZP) itself evoked no response but facilitated the dose- and time-dependently GABA-inducedI Cl without changing the GABA equilibrium potential (E GABA) at concentrations ranging widely, from 3 × 10−9 to 10−4 M. 3. In the presence of DZP, the… CONTINUE READING