Diazepam: in vitro effects on glucagon and insulin release.

  title={Diazepam: in vitro effects on glucagon and insulin release.},
  author={B Petrack and Andrew J. Czernik and W Itterly and Justin Ansell and Herbert Chertock},
  journal={Biochemical and biophysical research communications},
  volume={73 4},
Diazepam suppressed arginine-induced glucagon release from the isolated perfused rat pancreas in a dose-dependent manner, with an IC50 of approximately 65 microM. In contrast, insulin release was enhanced by 10-50 microM diazepam, but inhibited by higher concentrations of drug. Thus, 50 microM diazepam simultaneously suppressed glucagon and increased… CONTINUE READING