Diastolic stiffness as assessed by diastolic wall strain is associated with adverse remodelling and poor outcomes in heart failure with preserved ejection fraction.

@article{Ohtani2012DiastolicSA,
  title={Diastolic stiffness as assessed by diastolic wall strain is associated with adverse remodelling and poor outcomes in heart failure with preserved ejection fraction.},
  author={Tomohito Ohtani and Selma F. Mohammed and Kazuhiro Yamamoto and Shannon M. Dunlay and Susan A. Weston and Yasushi Sakata and Richard J. Rodeheffer and Veronique Lee Roger and Margaret M. Redfield},
  journal={European heart journal},
  year={2012},
  volume={33 14},
  pages={1742-9}
}
AIMS The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex but increased left ventricular (LV) diastolic stiffness plays a key role. A load-independent, non-invasive, direct measure of diastolic stiffness is lacking. The diastolic wall strain (DWS) index is based on the linear elastic theory, which predicts that impaired diastolic wall thinning reflects resistance to deformation in diastole and thus, increased diastolic myocardial stiffness. The objectives of… CONTINUE READING