Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.

@article{Johnson2013DiastolicSC,
  title={Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.},
  author={Daniel M. Johnson and Jordi Heijman and Elizabeth F. Bode and David J. Greensmith and Henk J. van der Linde and Najah Abi-Gerges and David J. Eisner and Andrew W. Trafford and Paul G. A. Volders},
  journal={Circulation research},
  year={2013},
  volume={112 2},
  pages={246-56}
}
RATIONALE Spontaneous Ca(2+) release (SCR) from the sarcoplasmic reticulum can cause delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during β-adrenergic stimulation. Excessive beat-to-beat variability of repolarization duration (BVR) is a proarrhythmic marker. Previous research has shown that BVR is increased during intense β-adrenergic stimulation, leading to SCR. OBJECTIVE We aimed to determine ionic mechanisms controlling BVR under these conditions… CONTINUE READING
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